Lincomycin Impurity

Lincomycin is a widely used clinical antibiotic with various types of preparations, including lincomycin hydrochloride eye drops, oral tablets, injections and etc.

Lincomycin is used clinically for a variety of infections caused by sensitive bacteria, including pneumonia, meningitis, endocarditis, cellulitis, tonsillitis, and dengue. Because of its ability to enter the bone tissue, it is especially suitable for infections caused by anaerobic bacteria and aureus osteomyelitis.

The mechanism of action of lincomycin is mainly through the action of the 50S subunit of the ribosome of sensitive bacteria, preventing the extension of the peptide chain, thus inhibiting the protein synthesis of bacterial cells. It is also bactericidal to highly sensitive bacteria at high concentrations.

Lincomycin may produce impurities during the manufacturing process that may pose a potential risk for clinical applications. Common lincomycin impurities include lincomycin hydrochloride, lincomycin sulfone, and lincomycin N-oxide. Pharmacopoeias of various countries have relevant regulations on the identification, inspection and content determination of their relevant substances.EP has a more complete control of impurities, while USP has no regulations on the control of relevant substances. The Chinese Pharmacopoeia uses C18 columns more commonly in the use of chromatographic columns, which have good durability but low sensitivity for the detection of impurities.

The study of these impurities can control potentially harmful substances in pharmaceuticals and reduce the risk of adverse reactions. SZEB supplies Lincomycin impurities with stable quality and high purity, the following is part of its catalogue, for more details of impurities,please go to the official website: www.ex-biotech.com