New impurity | Canagliflozin impurity 8

  Canagliflozin is used alone or in combination with other medications to treat type 2 diabetes in adults, along with a healthy diet and exercise, it can effectively improve blood sugar control. Canagliflozin is a sodium-glucose cotransporter-2 (SGLT2) inhibitor. It works by blocking SGLT2 and reducing the reabsorption of filtered glucose by the kidneys, lowering the renal threshold for glucose (RTG), and increasing urinary glucose excretion, thereby lowering blood sugar levels. Studies have shown that Canagliflozin is more effective than glipizide and sitagliptin in improving blood sugar control in patients with type 2 diabetes who are not well controlled with metformin, and has fewer side effects and is less likely to cause drug interactions.

  In 2019, the FDA approved the new indication of Canagliflozin "for adult patients with type 2 diabetes complicated with diabetic nephropathy to reduce the risk of end-stage renal disease, renal deterioration, cardiovascular death and hospitalization of heart failure". Since Canagliflozin was launched in China in 2018, the sales of sample hospitals have continued to grow and the market prospect is broad.

  The impurities of Canagliflozin mainly include open-ring impurities, defluorinated impurities, pentacyclic impurities, alpha isomers, acid impurities, dimers, acetylated isomers, unmethylated impurities and hydroxyl impurities。

   The study of impurities is the key to ensure the quality and stability of the drug efficacy, and the excellent pharmaceutical supply of all Canagliflozin  impurities.
The main impurity Canagliflozin  Impurity 8, CAS number: 90-80-2 Molecular formula: C6H10O6 Molecular weight: 178.14
Chemical formula:：(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-one

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